The relationship between bone-joint diseases and obesity

Abstract

The effects of obesity on the musculoskeletal system includes a wide range of diseases such as osteoarthritis, osteoporosis and systemic inflammatory rheumatic diseases. Studies on the subject have shown that there is a relationship between the presence of obesity, which is usually determined by BMI, and the prevalence and incidence of knee osteoarthritis. Gait analysis showed that weight loss is beneficial for reducing load across the knee joint, it was found that about 0.5 kg of weight loss reduces the load by two to four times per step. On the other hand, the effect of obesity on the protection of total bone metabolism by increasing bone formation and decreasing its dissolution should not be ignored for osteoporosis. Mediators called adipocytokines or adipokines are released from activated hypertrophic adipocytes in obese or overweight patients, and these adipokines with pro-inflammatory activities also have an effect on inflammatory rheumatic diseases. The effect of obesity in bone-joint diseases should not be ignored and it should be an important part of the treatment in the clinical approach. In this review, it is aimed to evaluate the effects of obesity on the musculoskeletal system in the light of current data.